Science

To see if they could develop a new drug that could overcome CRAB’s resistance, the researchers turned to a class of molecules called tethered macrocyclic peptides. Earlier studies on the compounds had revealed little antibiotic activity, but a screening of more than 45,000 of them showed that one was able to selectively kill A. baumannii. After a little tweaking, they tested the resulting drug, zosurabalpin, in mouse models of CRAB infection in pneumonia, a thigh wound and sepsis. The drug was effective in reducing the bacteria in all three groups and improved the rate of survival in the sepsis models. It was also effective in killing A. baumannii in more than 100 clinical samples.

https://www.fiercebiotech.com/research/roche-designs-new-antibiotic-fight-deadly-baumannii-infections