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58Sunliner

(5,886 posts)
4. The data helps define some parameters.
Thu Jul 20, 2023, 10:47 PM
Jul 2023

"We found that the distribution of deleterious variants in ACE2 differs among 9 populations in gnomAD (v3). Specifically, 39% (24/61) and 54% (33/61) of deleterious variants in ACE2 occur in African/African-American (AFR) and Non-Finnish European (EUR) populations, respectively (Fig. 1b). Prevalence of deleterious variants among Latino/Admixed American (AMR), East Asian (EAS), Finnish (FIN), and South Asian (SAS) populations is 2–10%, while Amish (AMI) and Ashkenazi Jewish (ASJ) populations do not appear to carry such variants in ACE2 coding regions (Fig. 1b)." That is not to say that ASJ or the Amish can't get Covid-19.
But looking at the numbers, you can see that even if you have a deleterious variant in ACE2 it has to be factored with everything else-'Various determinants of disease progression such as age, sex, virus mutations, comorbidity, lifestyle, host immune response, and genetic background variation have caused clinical variability of COVID-19. '
His original comments about it being engineered to spare the Chinese are ludicrous, of course. Many people died in China.

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