My company is short handed in various places around the country (Im sitting at a dock at a Postal Distribution Center in Billings, MT as I type this) so in the past 18 months I have flown from Jacksonville through or to California ( I was in Bakersfield when the airlines started mandating masks and flew home wearing one for the first time), several cities in Texas, Denver, Chicago, Seattle, Kansas City, Butte, Phoenix, Charlotte, Pittsburgh, Dulles, Newark, Atlanta, Salt Lake City and a few others I am probably forgetting.
It is true that modern airliners have a highly efficient air handling system and in all those flights I have yet to come across anyone that made a stink out of not wearing a mask.
And FWIW, I had my second Pfizer shot today, but being vaccinated didnt apply to all but one of the flights I have taken.
Im also a COPD patient, so I am keenly aware of the risks I was subjecting myself to, but I trust the science and I felt the risk was very small, as long as the crowds I was in (ie., an airplane cabin) were all wearing masks.
In short, I think it is safe, and as time moves on, it will get safer. I myself am looking forward to a trip to Europe, probably in 2022 or perhaps 23.
Consider your own health issues of course, but dont let fear dissuade you from travel.