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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsScientists think they found two key bacteria that cause multiple sclerosis
https://www.earth.com/news/scientists-think-they-found-two-key-bacteria-that-cause-multiple-sclerosis/"For decades scientists have combed the gut looking for bacteria in the microbiome that push the immune system toward multiple sclerosis (MS). New evidence from a rare twin study now points a clear finger at two species of bacteria that hide in the small intestine.
The study, which compared 81 pairs of genetically identical siblings, singled out Eisenbergiella tayi and Lachnoclostridium as the most likely triggers of the nerve‑damaging disorder.
Dr. Anna Peters of Ludwig Maximilian University of Munich steered the international team that linked these bacteria to disease in both people and mice.
Tracing clues in identical twins
Identical twins share nearly every gene, so differences in health are often related to outside factors. By focusing on twins where only one sibling had MS, the researchers stripped away much genetic noise."

ananda
(33,428 posts)Wow
radical noodle
(10,407 posts)Most of the people I know with MS had family members with MS.
cannabis_flower
(3,909 posts)But it takes the bacteria to trigger it.
radical noodle
(10,407 posts)I hope this turns into a cure eventually.
soldierant
(8,977 posts)for large chunks of their lives? I don't know how else these bacteria would get into the small intestine.
radical noodle
(10,407 posts)The ones I knew were like cousins.
womanofthehills
(10,408 posts)Many toxins (and viruses)
effect the central nervous system. Lots of autoimmune disorders out there now.
TrollBuster9090
(6,101 posts)You inherit a certain combination of gene alleles, which gives you a genetic predisposition to develop MS. But what triggers it (ie-environmental factors) has long been a mystery. At one time they thought it was exposure to pesticides. Now it appears that having certain bacteria in your gut microbiome is a risk factor. And those bacteria got there as a result of what you've been eating.
Interesting stuff!
By the way, something that I always thought was funny regarding medical genetic research. Looking at sets of identical twins has always been the 'Holy grail' for these kinds of studies. If you have an identical twin, you'll be hounded by scientists for your entire life to volunteer for studies.
Another funny thing about medical genetic research is that Salt Lake City Utah was always the Mecca of genetic research. Mainly because the Mormons practiced polygamy. And, to avoid accidentally marrying your second cousin, the Mormons kept extremely detailed family trees (pedigrees). Those are great for identifying diseases with a genetic component. For all the trash talking people do about Mormons, we owe them a debt of gratitude. A huge chunk of what we know about diseases with genetic components came from the Mormons volunteering their family pedigrees for genetic research.
ananda
(33,428 posts)Most of the time he was type O positive.
But every now and then it would shift to O negative.
When my younger sister was born, she had an RH
difficulty that completely baffled the doctors because
she was the sixth child and none of the ones before
her had it.
So they paid my dad to study his blood and that's
what they found.
Life can be very strange sometimes.
harumph
(3,022 posts)erronis
(21,431 posts)So many people around the world are debilitated (and die) from this disease.
I imagine that other diseases would also be able to be traced to our guts (and skin/mouth/etc.).
ClaudetteCC
(116 posts)This is one of several articles I've seen just in the past few months highlighting the health importance of the makeup of ones intestinal microbiome
electron_blue
(3,615 posts)I thought it was caused by that - wasn't that in the news lately?
eppur_se_muova
(40,143 posts)Nittersing
(7,657 posts)
wolfie001
(6,235 posts).....and tRUMP's closest BFF for 15 years.
Hassin Bin Sober
(27,274 posts)
angrychair
(11,178 posts)I know they mean scientists in other countries.
As is the case here.
It is not a mischaracterization to say that what is happening right now in the US-based scientific community is a literal apocalypse.
wolfie001
(6,235 posts)Him and his stupid conspiracy cabal.
mercuryblues
(15,884 posts)Maybe trump? Vance?
BComplex
(9,572 posts)So many people's lives could be restored if there was a cure for MS!
ProfessorGAC
(74,631 posts)This definitely interests me as I've had MS for a bit over 30 years.
My recent scans appear identical to those from 2000. And, my condition at that point hadn't changed for a couple years.
I wonder if a natural or organic reduction in these two bacterial strains could explain a remission that has lasted over a quarter century.
Nittersing
(7,657 posts)Pretty exciting stuff.
electric_blue68
(24,042 posts)TrollBuster9090
(6,101 posts)1. I have MS in my family. My mother developed it when I was 14, and I've been dealing with it, one way or another, for the last 50 years.
2. I teach clinical microbiology and genetics. I'm always looking for good, interesting research papers to show to my students. I was even up last night looking for them on PUBMED. But I never IMAGINED that I'd find an interesting paper on DU! Thanks for finding that!!
WestMichRad
(2,666 posts)TY for posting this news.
0rganism
(25,340 posts)I hope this leads to a cure. My life might be basically over due to damage from this shitty disease, but younger patients could benefit radically. I'll talk with my neurologist about volunteering for treatment studies that emerge as a result. Thanks for posting!